Scientific publications on transdifferentiation from our laboratory

Centre for Regenerative Medicine ,
Department of Biology and Biochemistry,
University of Bath,
Bath BA2 7AY, UK.

Shen, C.N., Petiot , A., Chien, C-Y, Dickson , C., Slack, J.M.W. and Tosh, D. All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas. Differentiation in press.

Westmacott, A., Burke, Z.D., Slack, J.M.W. and Tosh, D. C/EBPα and C/EBPß are early markers of liver development. Int. J. Dev. Biol. in press.

Burke, Z.D., Shen, C-N., Ralphs, K and Tosh, D. (2006). Characterization of liver function in transdifferentiated hepatocytes. J Cellular Physiology 206, 147-159

Tosh, D. (2006). Chapter 22: Differentiation of pancreatic cells into hepatocytes. Cell Biology: A Laboratory Handbook. Elsevier Editors: Celis, Carter, Simmons, Small, Hunter, Shotton.

Li, W-C., Yu, W-Y, Quinlan, J.M., Burke, Z.D. and Tosh, D. (2005). Molecular basis of transdifferentiation. Journal of Cellular and Molecular Medicine 9, 569-582

Wang, R.Y-L., Shen, C-N., Lin, M-H., Tosh, D and Shih, C. (2005). Hepatocyte-like cells transdifferentiated from pancreatic origin can support replication of Hepatitis B virus. Journal of Virology 79, 13116-13128

Yu, W.Y., Slack, J.M.W. and Tosh, D. (2005) Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus. Dev. Biol. 284, 157-170.

Li, W.C., Horb, M. E. , Tosh, D. and Slack, J.M.W.. (2005) In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mech. Dev. 122, 835-847

Burke, Z.D. and Tosh, D. (2005). Therapeutic potential of transdifferentiated cells. Clinical Science 108, 309-321.

Tosh, D. and Strain, A.J. (2005). Liver Stem Cells – Prospects for clinical use. Journal of Hepatology 42, S75-S84.

Burke, Z. D., Shen, C. N. and Tosh, D. (2004). Bile ducts as a source of pancreatic beta cells. Bioessays 26, 932-937.

Shen, C-N., Burke Z.D. and Tosh, D. (2004). Transdifferentiation, metaplasia and tissue regeneration. Organogenesis 1, 36-44.

Tosh, D and Horb, M.E. (2004). How cells change their phenotype. Chapter 12: Handbook of Adult & Fetal Stem Cells. Academic Press Editors: Lanza, Blau, Melton, Moore, Donnall, Thomas, Verfaillie, Weissman and West.

Burke, Z. D., Shen, C. N. and Tosh, D. (2004). Bile ducts as a source of pancreatic ß-cells. Bioessays 26, 932-937.

Slack J.M.W. (2004). Intestine in the lung. J.Biol. 3, 1-4.

Kurash, J. K., Shen, C. N. and Tosh, D. (2004). Induction and regulation of acute phase proteins in transdifferentiated hepatocytes. Experimental Cell Research 292, 342-358.

Horb, M.E., Shen, C.N., Tosh, D. and Slack, J.M.W. (2003). Experimental conversion of liver to pancreas. Current Biology 13, 105-115.

Shen, C-N., Seckl, J.R., Slack, J.M.W. and Tosh, D. (2003). Glucocorticoid inhibits insulin expression and induces transdifferentiation in embryonic pancreas. Biochem. J 375, 41-50.

Tosh, D., Shen, C-N., Horb, M. and Slack, J.M.W. (2003). Transdifferentiation of pancreas to liver. Mech. Dev. 120, 107-116

Tosh D. and Slack J.M.W. (2002). How cells change their phenotype. Nature Reviews Molecular Cell Biology. 3, 187-194.

Tosh, D., Shen, C-N. and Slack, J.M.W. (2002). Differentiated properties of hepatocytes induced from pancreatic cells. Hepatology, 36, 534-543.

Tosh, D., Shen, C-N and Slack, J.M.W. (2002). Conversion of pancreatic cells to hepatocytes. Biochem. Soc. Trans. 30, 51-54.

Slack, J.M.W. and Tosh, D. (2001). Transdifferentiation and metaplasia - switching cell types. Curr. Op. Genetics Dev. 11, 581-586.

Shen, C.N., Slack, J.M.W. and Tosh, D. (2000). Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology, 2, 879-887.

Slack, J.M.W. (2000). Stem cells in epithelial tissues. Science 287, 1431-1433.

Slack, J.M.W. (1995). The developmental biology of the pancreas. Development 121, 1569-1580.

Slack, J.M.W. (1986) Epithelial metaplasia and the second anatomy. The Lancet, August 2nd, 267-271.

Slack, J.M.W. (1985) Homoeotic transformations in Man. Implications for the mechanism of embryonic development and for the organization of epithelia. J. Theor. Biol. 114, 463-490.